The Crosswalk

    COFEPRIS

    Flag of MexicoMexico — COFEPRIS

    GuidanceLast updated · 2024Verified · 2026-05-28

    NOM-241-SSA1-2021 + COFEPRIS digital-health criteria

    Authority

    Comisión Federal para la Protección contra Riesgos Sanitarios

    Enforced

    Dec 2021 (NOM-241)

    Legal framework

    Ley General de Salud + NOM-241-SSA1-2021 + LFPDPPP

    FDA package reuse

    ~90%

    Scope

    Medical devices and SaMD marketed in Mexico. Cybersecurity expectations folded into Good Manufacturing Practices.

    Pre-market

    Risk management dossier, software lifecycle evidence, evidence reuse from FDA / Health Canada accepted via equivalence.

    Post-market

    Tecnovigilancia reporting, software change notifications.

    SBOM

    Recommended

    Encouraged in technical file, not strictly mandated.

    Vulnerability disclosure

    Encouraged via CERT-MX coordination.

    Penalty

    Sanitary registration suspension, fines under General Health Law.

    Unique requirements

    • 01Mexican Registration Holder (Titular)
    • 02Spanish-language IFU and labelling
    • 03Equivalence dossier accelerates approval

    Highlights

    • Equivalence route for FDA / Health Canada
    • Top-3 LATAM market by device spend
    • NOM-241 GMP compliance underpins everything

    Aligns with

    IMDRF N60 FDA 2023 Guidance ISO 13485

    Timeline

    1. Dec 2021

      NOM-241-SSA1-2021 published

    2. 2023

      Equivalence agreements broadened

    3. 2024

      Digital-health criteria refined

    Key documents

    Related markets

    Frequently asked about Mexico

    Is SBOM required for medical devices in Mexico?

    Recommended. Encouraged in technical file, not strictly mandated.

    What does COFEPRIS require for pre-market cybersecurity?

    Risk management dossier, software lifecycle evidence, evidence reuse from FDA / Health Canada accepted via equivalence.

    What are the post-market cybersecurity obligations under COFEPRIS?

    Tecnovigilancia reporting, software change notifications.

    What is the penalty for non-compliance with COFEPRIS cybersecurity rules?

    Sanitary registration suspension, fines under General Health Law.

    How much of my FDA cybersecurity package is reusable in Mexico?

    Roughly 90% — an editorial estimate based on overlapping evidence requirements (threat model, SBOM, security risk assessment, pen-test report).